AstraZeneca Plc is a holding company, which engages in the research, development, and manufacture of pharmaceutical products. It operates through the following geographical segments: UK; Continental Europe; The Americas; Asia, Africa & Australasia. It produces and commercializes medicines for gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology, and infectious diseases. It distributes its products under the following brands: Atacand, Crestor, Onglyza, Nexium, Entocort, Losec, Merrem/Meronem, Carbocaine, Citanest, Diprivan, Marcaine/Sensorcaine. The company was founded on April 6, 1999 and is headquartered in London, the United Kingdom.